DESBOIS Nicolas See the English profil sheet

2011             Maître de Conférences (section 86) UFR Santé, Dijon
                     ICMUB (Institut de Chimie Moléculaire de l’Université de Bourgogne) UMR CNRS 6302
2006-2011    Maître de Conférences (section 86) UFR Santé, Dijon
                     Equipe INSERM CRI U866
2005-2006    ATER INSERM 484 Université d’Auvergne, Clermont Ferrand
                     Radiomarquage (¹²⁵I),Tests de cytotoxicité (test résazurine, test de Hoechst), Test topoisomérase I, test clonogénique
 2002-2005   Doctorat, Laboratoire de Chimie Organique UFR Pharmacie de l’Université d’Auvergne, Clermont Ferrand
                     Directeur de Thèse : Pr Jean Claude Teulade, Co-encadrant : Pr Jean Michel Chezal
                     Concept, synthèse et mécanisme d'action de motifs hétéroaromatiques à visée radiochimiothérapeutique interne du mélanome
2001-2002    DEA Conception, synthèse, analyse et structure des composés d’intérêt biologique
                     Institut de Chimie Organique et Analytique d'Orléans (ICOA)

ANR CO3SENS : Etude d’un capteur à ondes élastiques de surface à base de corroles de cobalt dédié à la détection du monoxyde de carbone (255 k€, 2015-2019)
VIRCO SATT SAYENS : Antiviraux herpès virus (hCMV) et poxvirus (MYXV) à base de corroles (475 k€, 2018-2019)

Programme international de mobilité : PHC Procore avec Hong-Kong (2017-2018)

Activité de recherche :

Synthèse et caractérisation physicochimique de ligands et complexes métalliques à base de dérivés porphyriniques (porphyrines, corroles, bactériochlorines, chlorines, sapphyrines…).

Brevets

2. Claude P. Gros, Nicolas Desbois, Franck Gallardo, Corroles for treating POXVIRUS infection, 2017,EP 17306656.4, WOBI17SREPOX

1. Claude P. Gros, Nicolas Desbois, Franck Gallardo, Corroles for treating Human Cytomegalovirus infections, 2017, EP 17306655.4, WOBI17SRECMV

 Publications

47. Ponsot F.; Desbois N.; Bucher L; Berthelot M.; Mondal P.; Gros C. P.; Romieu A. Near-infrared emissive bacteriochlorin-diketopyrrolopyrrole triads: Synthesis and photophysical properties Dyes and Pigments, 2019, 160, 747-756.

46. Yang J.; Rousselin Y.; Bucher L.; Desbois N.; Bolze F.; Xu H-J.; Gros C. P. Two-photon absorption properties and structures of BODIPY and its Dyad, Triad and Tetrad ChemPlusChem, 2018, 83(9), 838-844.

45. Quesneau V.; Shan W.; Desbois N.; Brandès S.; Rousselin Y.; Vanotti M.; Blondeau-Patissier V.; Naitana M.; Fleurat-Lessard P.; Van Caemelbecke E.; Kadish K. M.; Gros C. P. Cobalt Corroles with bis-Ammonia or mono-DMSO Axial Ligands. Electrochemical, Spectroscopic Characterizations and Ligand Binding Properties Eur. J. Inorg. Chem., 2018, 38, 4265-4277.

44. Bucher L.; Desbois N.; Harvey P. D.; Gros C. P.; Misra R.; Sharma G. D. Non‑fullerene/Polymer Solar Cells Reaching a 9.29% Efficiency Using a BODIPY-thiophene Backboned Donor Material ACS Appl. Energy Mater., 2018, 1(7), 3359-3368.

43. Bucher L.; Desbois N.; Koukaras E. N; Devillers C. H.; Biswas S.; Sharma G. D.; Gros C. P. BODIPY-diketopyrrolopyrrole-porphyrin conjugate Small Molecules for Use in Bulk Heterojunction Solar Cells J. Mat. Chem. A, 2018, 6(18), 8449-8461.

42. Jiang X.; Shan W.; Desbois N.; Quesneau V.; Brandès S.; Van Caemelbecke E.; Osterloh W. R.; Blondeau-Patissier V.; Gros C. P.; Kadish K. M. Mono-DMSO Ligated Cobalt Nitrophenylcorroles: Electrochemical and Spectral Characterization New J. Chem., 2018, 42, 8220-8229.

41. Miyake Y.; López Moreno A.; Yang J.; Xu H-J.; Desbois N.; Gros C. P.; Komatsu N. Synthesis of flexible nanotweezers with various metals and their application to carbon nanotube extraction New J. Chem., 2018, 42, 7592-7594.

40. Gros C. P.; Michelin C.; Bucher L.; Desbois N.; Devillers C. H.; Coutsolelos A. G.; Biswas S.; Sharma G. D. Synthesis and characterization of zinc carboxy-porphyrin complexes for dye sensitive solar cells New J. Chem., 2018, 42, 8151-8159.

39. Jiang X.; Naitana M.; Desbois N.; Quesneau V.; Brandès S.; Rousselin Y.; Shan W.; Blondeau-Patissier V.; Gros C. P.; Kadish K. M. Electrochemistry of Bis-pyridine Cobalt Nitrophenylcorroles in Nonaqueous Media Inorg. Chem., 2018, 57(3), 1226-1241.

38. Bucher L.; Desbois N.; Harvey P. D.; Gros C. P.; Sharma G. D. A Porphyrin Antenna-enriched BODIPY-thiophene copolymer for Efficient Solar Cells ACS Appl. Mater. Interfaces, 2018, 10(1), 992-1004.

37. Bucher L.; Tanguy L.; Desbois N.; Karsenti P-L.; Harvey P. D.; Gros C. P.; Sharma G. D. Photovoltaic Properties of a Porphyrin-containing Polymer as Donor in Bulk Heterojunction Solar Cells with Low Energy Loss Solar RRL, 2018, 2(1), 1-9.

36. Bucher L.; Desbois N.; Harvey P. D.; Sharma G. D.; Gros C. P. Porphyrins and BODIPY as Building Blocks for Efficient Donor Materials in Bulk Heterojunction Solar Cells Solar RRL, 2017, 1(12),1-26.

35. Vanotti M.; Theron C.; Poisson S.; Quesneau V.; Naitana M.; SoumannV.; Brandès S.; Desbois N.; Gros C. P.; Tran-Thi T.; Blondeau-Patissier V. Surface Acoustic Wave sensors for the detection of hazardous compounds in indoor air Proceedings, 2017, 1, 444; doi:10.3390/proceedings1040444.

34. Shan W.; Desbois N.; Blondeau-Patissier V.; Naitana M. L.; Quesneau V.; Rousselin Y.; Gros C. P.; Ou Z.; Kadish K. M. Synthesis, Characterization and Electrochemistry of Open-Chain Pentapyrroles and Sapphyrins with Highly Electron Withdrawing meso-Tetraaryl substituents Chem. Eur. J., 2017, 23, 12833-12844.

33. Jiang X.; Gros C. P.; Chang Y.; Desbois N.; Zeng L. Cui Y.; Zeng L.; Kadish K. M. Tetraanionic and Tetracationic Manganese Porphyrins: Electrochemical and Spectroelectrochemical Characterization Inorg. Chem., 2017, 56(4), 8045-8057.

32. Fang Y.; Zhu J.; Cui Y.; Zeng L.; Naitana M. L.; Chang Y.; Desbois N.; Gros C. P.; Kadish K. M. Protonation and Electrochemical Properties of Pyridyl and SulfonatophenylSubstituted Porphyrins in Nonaqueous Media ChemElectroChem, 2017, 4(8), 1872-1884.

31. Bucher L.; Aly S. M.; Desbois N.; Karsenti P-L.; Gros C. P.; Harvey P. D. Random structural modification of a low band gap BODIPY-based polymer J. Phys. Chem., 2017, 121(12), 6478-6491.

30. Bucher L.; Tanguy L.; Fortin D.; Desbois N.; Gros C. P.; Harvey P. D. A very low bandgap (diketopyrrolopyrrole-porphyrin) conjugated polymer ChemPlusChem., 2017, 82(4), 625-630.

29. Deschamps J.; Langlois A.; Martin G.; Bucher L.; Desbois N.; Gros C. P.; Harvey P. D. Cyclotriveratrylene-containing Porphyrins, Inorg. Chem., 2016, 55, 9230-9239.

28. Diabate P. D; Laguerre A.; Pirrotta M.; Desbois N.; Boudon J.; Gros C. P.; Monchaud D. DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool New. J. Chem., 2016, 40, 5683-5689. Themed collection on Nitrogen Ligands. Cover of issue 07 July 2016

27. Deschamps J.; Chang Y.; Langlois A.; Desbois N.; Gros C. P.; Harvey P. D.The First Example of Cofacial Bis(dipyrrinphenol)s New. J. Chem., 2016 Themed collection on Nitrogen Ligands 2016, 40, 5835-5845.

26. Pascal S.; Bucher L.; Desbois N.; Bucher C.; Andraud C.; Gros C. P Synthesis, Electrochemistry and Photophysics of Aza-BODIPY Porphyrin Dyes Chem. Eur. J., 2016, 22, 4971-4979.

25. Gros C.P.; Michelin, C.; Depotter G.; Desbois N.; Clays K.; Cui Y.; Zeng L.; Fang Y.; Ngo H. M.; Lopez C.; Ledoux I.; Nicoud J.-F.; Bolze F.; Kadish K. M. Non-Linear Optical, Electrochemical and Spectroelectrochemical Properties of Amphiphilic Inner Salt Porphyrinic Systems J. Porphyrins Phthalocyanines, Special Issue dedicated to Thomas Torres, 2016, 20, 1006-1015.

24. Cui Y.; Zeng L.; Fang Y.; Zhu J.; Devillers C. H.; Lucas D.; Desbois N.; Gros C. P.; Kadish K. M. Tuning the Electrochemistry of Free-Base Porphyrins in Acidic Nonaqueous Media: Influence of Solvent, Supporting Electrolyte and Ring Substituents ChemElectroChem, 2016, 3, 228-241.

23. Desbois N.; Michelin C.; Chang Y.; Bonnaud M.; Pacquelet S.; Gros C. P. Synthetic strategy for preparation of a folate corrole DOTA heterobimetallic Cu-Gd complex as a potential bimodal contrast agent in medical imaging Tetrahedron Lett., 2015, 56, 7128-7131.

22. Desbois N.; Pacquelet S.; Dubois A.; Michelin C.; Gros C. P. Easy access via microwave-enhanced cycloaddition to heterobimetallic complexes for medical imaging applications Beilstein J. Org. Chem., 2015, 11, 2202–2208.

21. Cui Y.; Zeng L.; Fang Y.; Zhu J., Xu H-Y.; Desbois N.; Gros C. P.; Kadish K. M. Electrochemical and Spectroelectrochemical Properties of Free-Base Pyridyl- and N-Alkyl-4-Pyridylporphyrins in Nonaqueous Media ChemElectroChem, 2016, 3(1), 110-121.

20. Gros C. P.; Desbois N.; Michelin C.; Demilly E.; Tilkin-Mariamé A-F.; Mariamé B.; GallardoF. Synthesis and antiviral activity evaluation of nitroporphyrins and nitrocorroles as potential agents for human cytomegalovirus infection ACS Infect. Dis., 2015, 1(8), 350-356. Cover of the August 2015.

19. Chang Y.; Michelin C.; Bucher L.; Desbois N.; Gros, C. P.; Piant S.; Bolze F.; Fang Y.; Jiang X.; Kadish K. M. Synthesis and Characterization of Carbazole Linked Porphyrin Tweezers Chem. Eur. J., 2015, 21(34), 12018-12025. Hot Paper, Inside Front Cover.

18. Laguerre A.; Chang Y.; Pirrotta M.; Desbois N.; Gros C. P.; Lesniewska E.; Monchaud D. Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures Org. Biomol. Chem., 2015, 13(25), 7034-7039.

17. Fang Y.; Jiang X.; Ou Z.; Michelin C.; Desbois N.; Gros C. P.; Kadish K. M. Redox Properties of Nitrophenylporphyrins and Electrosynthesis of Nitrophenyl-Linked Zn Porphyrin Dimers or Arrays. J. Porphyrins Phthalocyanines, 2014, 18(8-9), 832-841. Dedicated to Professor Nagao Kobayashi on the occasion of his 65th birthday.

16. Gardette M.; Viallard C.; Paillas S.; Guerquin-Kern J-L.; Papon J.; Moins N.; Labarre P.; Desbois N.; Wong-Wha-Shung P.; Palle S.; Wu T-D.; Pouget J-P.; Miot-Noirault E.; Chezal J-M.; Degoul F. Evaluation of two ¹²⁵I radiolabeled acridine derivatives for Auger-Electron radionuclide therapy of melanoma. New Invest. Drugs, 2014, 32(4), 587-597.

15. Brizet B.; Desbois N.; Bonnot A; Langlois A.; Dubois A.; Barbe J-M.; Gros C. P.; Goze, C.; Denat F.; Harvey P. D. Slow and fast singlet energy transfers in BODIPY-gallium(III)corrole dyads linked by flexible chains. Inorg. Chem. 2014, 53(7), 3392-3403.

14. Laguerre A.; Desbois N.; Stefan L.; Richard P.; Gros C. P.; Monchaud D. Porphyrin-based design of bioinspired multitarget quadruplex ligands. ChemMedChem, 2014, 9(9), 2035-2039. Special Issue: DNA & RNA Medicinal Chemistry.

13. Eggenspiller A.; Michelin C.; Desbois N.; Richard P.; Barbe J-M.; Denat F.; Licona C.; Gaiddon C.; Sayeh A.; Choquet P.; Gros C. P. Design of porphyrin-DOTA-like scaffolds as all-in-one multimodal heterometallic complexes for medical imaging. Eur. J. Org. Chem., 2013, 29, 6629-6643.

12. Desbois N.; Pertuit D.; Moretto J.; Cachia C.; Chauffert B.; Bouyer F. Cis-dichloroplatinum(II) complexes tethered to dibenzo[c,h] [1,6]naphthyridin-6-ones: synthesis and cytotoxicity in human cancer cell lines in vitro Eur. J. Med. Chem., 2013, 69, 719-727.

11. Pacquelet S.; Blache Y.; Kimny T.; Lacaille-Dubois M-A.; Desbois N. Convenient synthesis of heterocyclic compounds with dihydropyrano[3,4-b]pyridine scaffold Synth. commun., 2013, 43(8), 1092-1100.

10. Bouyer F.; Moretto J.; Pertuit D.; Szollosi A.; Lacaille-Dubois M-A.; Blache Y.; Chauffert B.; Desbois N. Synthesis, cytotoxicity and structure-activity relationships between ester and amide functionalities in novel acridine-base platinum(II) complexes J. Inorg. Biochem., 2012, 110, 51-57.

9. Gardette M.; Papon J.; Bonnet M.; Desbois N.; Labarre P.; Wu T. D.; Miot-Noirault E.; Madelmont J. C.; Guerquin-Kern J. L.; Chezal J.M.; Moins N. Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using (125)I, an Auger electron emitter Invest. New Drugs, 2011, 29(6), 1253-1263.

8. Gardette M.; Papon J.; Palle S.; Guerquin-Kern J. L.; Labarre P.; Desbois N.; Noirault E.; Bonnet M.; Chezal J. M.; Moins N. Preclinical evaluation of acridine-derived vectors for internal radiotherapy of melanoma by an issuer of election Auger: Iodine 125 Bull. Cancer, 2010, 97 (Sp. Iss.), S11-S12.

7. Yapi A. D.; Desbois N.; Chezal J. M.; Chavignon O.; Teulade J. C.; Valentin A.; Blache Y. Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities Eur. J. Med. Chem., 2010, 45(7), 2854-2859.

6. Desbois N.; Szollosi A.; Maisonial A.; Weber V.; Moreau E.; Teulade J. C.; Chavignon O.; Blache Y.; Chezal J. M. Simple and convenient conversion of acridones into 9-unsubstituted acridines via acridanes using borane tetrahydrofuran complex Tetrahedron Lett., 2009, 50, 6894-6896.

5. Sall, C.; Desbois, N.; Paquelet, S.; Camacho, J. R.; Chezal, J. M.; Teulade, J. C.; Blache, Y. An efficient route to a 5,6-dihydropyrano[3,4-b]pyridin-8-one core in two steps from enaminolactones Tetrahedron Lett., 2008, 49, 1301-1304.

4. Sall, C.; Yapi, A. D.; Desbois, N.; Chevalley, S.; Chezal, J. M.; Tan, K.; Teulade, J. C.; Valentin, A.; Blache, Y. Design, synthesis, and biological activities of conformationally restricted analogs of primaquine with a 1,10-phenanthroline framework Bioorg. Med. Chem. Lett., 2008, 18, 4666-4669.

3. Desbois, N.; Gardette, M.; Papon, J.; Labarre, P.; Maisonial, A.; Auzeloux, P.; Lartigue, C.; Bouchon, B.; Debiton, E.; Blache, Y.; Chavignon, O.; Teulade, J. C.; Maublant, J.; Madelmont, J. C.; Moins, N.; Chezal, J. M. Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma Bioorg. Med. Chem., 2008, 16, 7671-7690.

2. Desbois, N.; Chezal, J-M.; Fauvelle, F.; Debouzy, J-C.; Lartigue, C.; Gueiffier, A.; Blache, Y.; Moreau, E.; Madelmont, J-C.; Chavignon, O.; Teulade, J-C. Synthesis of polyfused Heterocycle derivatives containing the dipyridoimidazole core by Friedländer's reaction: access to analogs of Ellipticine Heterocycles, 2005, 65, 1121-1137.

1. Chezal, J-M.; Moreau, E.; Desbois, N.; Blache, Y.; Chavignon, O.; Teulade, J-C. Synthesis of carbamoylpyridine and imidazo[1,5-a]pyridin-1,3-diones via ortho-acetalhydantoin intermediates. Tetrahedron Lett., 2004, 45, 553-556.

Responsabilités

Responsable de la 2^ème année de Pharmacie (DFGSP2) depuis 2012
Responsable des EC Voies d’accès aux substances médicamenteuses (DFGSP2 et DFGSP3) et de l’UE librement choisie Accès aux substances actives médicamenteuses : une approche expérimentale (DFGSP2)

Ouvrages

Co-auteur de 4 ouvrages de Chimie parus aux éditions Ellipses :

« La Chimie en PACES, UE1 Rappels de cours et QCM type concours » Claude Gros & Nicolas Desbois Editions Ellipses, ISBN 9782340-027497 4ème Edition - 380 pages Paru en août 2018.	« La Chimie en PACES, UE1 Rappels de cours et QCM type concours » Claude Gros & Nicolas Desbois Editions Ellipses, ISBN : 9782340014213 3ème Edition - 352 pages Paru en août 2016.
« La Chimie en PACES, UE1 Rappels de cours et QCM type concours » Claude Gros & Nicolas Desbois Editions ellipses, ISBN : 9782729886882 2nde Edition - 326 pages Paru en juillet 2014.	« La Chimie en PACES, UE1 Rappels de cours et QCM type concours » Claude Gros & Nicolas Desbois Editions Ellipses, ISBN : 978272987415 1ère Edition - 270 pages Paru en juillet 2012 ( 2500 ex.)

Enseignements

PACES
UE1 Atomes Biomolécules (ED)
UE Spécifique Pharmacie, Chimie Organique (ED)

2^ème année de Pharmacie
UE Sciences du Médicament 1, Voies d’accès aux substances médicamenteuses (ED, CM, TP)
UE Sciences du Médicament 2, Cycle de vie du médicament (ED, CM)
UE librement choisie, Accès aux substances actives médicamenteuses : une approche expérimentale (ED, CM, TP)

3^ème année de Pharmacie
UE Sciences du Médicament 1, Voies d’accès aux substances médicamenteuses (ED, CM)

Master Santé
UE optionnelle Conception et structure des molécules d’intérêt thérapeutique (ED, CM, TP)

The LipTherapI international Master
Upgrading Chemistry (CM)