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Dr Victor GONCALVES, Assistant Professor


Information
Academic organism : University of Burgundy

Office : B-R27B

Phone: +33 (0)3 80 39 60 88

E-mail : Victor.Goncalves(at)u-bourgogne.fr

Education/Research Team : P2DA (Polyamines, Porphyrins, Developments and Applications)

Victor Goncalves - ICMUB - Université de Bourgogne

Biography

Since 2012 : Assistant Professor in Chemistry, Université de Bourgogne - ICMUB
2009-2012 : Post-doctoral Research Associate in Medicinal Chemistry, Imperial College London
Groups of Dr Ed Tate and Pr Robin Leatherbarrow
2008-2009 : Post-doctoral Research Scientist in Medicinal Chemistry, Sanofi-Aventis, Toulouse - France
Project leaders : Alain Badorc and Jean-Pierre Maffrand
2008 : PhD in Medicinal Chemistry, University Paris Descartes, in the Group of Pr Nicolas Inguimbert and Michel Vidal
2005 : MRes (DEA) in Medicinal Chemistry, Pharmacology and Drug Metabolism, University Paris Descartes
2005 : Ecole Nationale Supérieure de Chimie de Paris, Paris - (Chimie ParisTech)


Publications

18 - 89Zr-immunoPET in oncology: state of the art 89Zr-radiochemistry.
S. Heskamp, R. Raavé, O.C. Boerman, M. Rijpkema, V. Goncalves, F. Denat
Bioconjugate Chemistry (2017)

17 - Structure-guided optimization of quinoline inhibitors of Plasmodium N- myristoyltransferase
V. Goncalves, J. A. Brannigan, A. Laporte, A. S. Bell, S. M. Roberts, A. J. Wilkinson, R. J. Leatherbarrow, E. W. Tate
MedChemComm (2017), 8, 191-197

16 - Direct subphthalocyanine conjugation to bombesin vs indirect conjugation to its lipidic nanocarrier
Y. Bernhard, E. Gigot, V. Goncalves, M. Moreau, N. Sok, P. Richard, R.A. Decréau
Organic & Biomolecular Chemistry (2016), 14 (19), 4511-4518

15 - (R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors
E. Gourni, C. Canovas, V. Goncalves, F. Denat, P.T. Meyer, H.R. Maecke
PLoS One (2015), 10 (12), e0145755

14 - BODIPY-polyazamacrocycles as bimodal probes for molecular imaging
D. Lhenry, M. Larrouy, C. Bernhard, V. Goncalves, O. Raguin, P. Florent, M. Moreau, B. Collin, A. Oudot, J-M.Vrigneaud, F. Brunotte, C. Goze, F. Denat
Chemistry - A European Journal (2015), 21 (37), 13091-13099.

13 - MA-NOTMP: a triazacyclononane-trimethylphosphinate based bifunctional chelator for gallium-radiolabelling of biomolecules
S. Poty, P. Désogère, J. Šimeček, C. Bernhard, V. Goncalves, C. Goze, F. Boschetti, J. Notni, H.J. Wester, F. Denat
ChemMedChem (2015), 10, 1475-1479.

12 - Towards the elaboration of new gold-based optical theranostics
P-E. Doulain, R. Decréau, C. Racoeur, V. Goncalves, L. Dubrez, A. Bettaieb, P. Le Gendre, F. Denat, C. Paul, C. Goze, E. Bodio.
Dalton Transactions (2015), 44 (11), 4874-4883

11 - DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET–Optical Imaging
B. Brizet, V. Goncalves, C. Bernhard, P. D. Harvey, F. Denat, C. Goze.
Chemistry - A European Journal (2014), 20 (40), 12933-12944

10 - Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors
J.A. Hutton, V. Goncalves, J.A. Brannigan, D. Paape, M.H. Wright, T.M. Waugh, S.M. Roberts A.S. Bell, A.J. Wilkinson, D.F. Smith, R.J. Leatherbarrow, E.W. Tate.
Journal of Medicinal Chemistry (2014), 57 (20), 8664-8670

09 - Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: Screening, synthesis, and structural characterization of their binding mode
V. Goncalves, J.A. Brannigan, D. Whalley, B. Saxty, A.A. Holder, A.J. Wilkinson, E.W. Tate, R.J. Leatherbarrow.
Journal of Medicinal Chemistry (2012), 55 (7), 3578-3582


08 - A fluorescence-based assay for N-myristoyltransferase activity.
V. Goncalves, J.A. Brannigan, E. Thinon, T.O. Olaleye, R. Serwa, S. Lanzarone, A.J. Wilkinson, E.W. Tate, R.J. Leatherbarrow
Analytical Biochemistry (2012), 421 (1), 342-344


07 - Targeting the pro-angiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening
B. Gautier, M.A. Miteva, V. Goncalves, F. Huguenot, C. Garbay, A. Lesnard, S. Rault, N. Inguimbert, Bruno O. Villoutreix, Michel Vidal
Chemistry & Biology (2011), 18 (12), 1631-1639


06 - Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist
B. Gautier, V. Goncalves, D. Diana, R. Di Stasi, F. Teillet, C. Lenoir, F. Huguenot, C. Garbay, R. Fattorusso, L. Domenico D'Andrea, M. Vidal, N. Inguimbert.
Journal of Medicinal Chemistry (2010), 53, 11, 4428-4440


05 - Total chemical synthesis of the D2 domain of human VEGF receptor 1
V. Goncalves, B. Gautier, F. Huguenot, P. Leproux, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Peptide Science (2009), 15 (6), 417-422


04 - Structure-based design of a bicyclic peptide antagonist of the Vascular Endothelial Growth Factor Receptors
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Peptide Science (2008), 14 (6), 767-772


03 - On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition
V. Goncalves, B. Gautier, A. Regazzetti, P. Coric, S. Bouaziz, C. Garbay, M. Vidal, N. Inguimbert.
Bioorganic and Medicinal Chemistry Letters (2007), 17, 5590-5594


02 - Rational design, structure and biological evaluation of cyclic peptides mimicking the Vascular Endothelial Growth Factor
V. Goncalves, B. Gautier, P. Coric, S. Bouaziz, C. Lenoir, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Medicinal Chemistry (2007), 50 (21), 5135-5146


01 - Development of a chemiluminescent screening assay for Vascular Endothelial Growth Factor Receptor 1 ligands
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Analytical Biochemistry (2007), 366 (1), 108-110


Conference Proceedings

Preclinical evaluation of a Ga-68-and Cu-64-labeled urea-based inhibitor of the prostate specific membrane antigen (PSMA). A promising diagnostic radiopharmaceutical for prostate cancer imaging.
E. Gourni, V. Goncalves, F. Denat, P.T. Meyer, H.R. Maecke.
Journal of Labelled Compounds & radiopharmaceuticals (2015), 58, S59

NODA-GA-PSMA: A versatile probe for SPECT/PET imaging of PSMA-positive tumors.
E. Gourni, V. Goncalves, F. Denat, P.T. Meyer, H.R. Maecke.
European Journal of Nuclear Medecine and Molecular Imaging (2015), 42, S174

Cyclic peptides as VEGF receptor antagonist
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Biopolymers (2007), 88 (4), 541-541
Adv Exp Med Biol (2009), 611, 479-80

Synthesis of the S129-1229 fragment of the extracellular domain of the VEGF receptor I embedding the ligand binding site
V. Goncalves, B. Gautier, F. Huguenot, C. Garbay, M. Vidal, N. Inguimbert
Journal of Peptide Science (2008), 14 (8), 81-81


Student/Postdoc

2017-2018: Laurène DA COSTA (Postdoc)
2017-2020: Emma RENARD (PhD)
2017: Aurélien GIBIER (Master 2 CMPP)
2017: Alexis HERVEAUX (L2 SV Dijon), Mylène BONNIER (L3 Chimie Dijon)
2016: Patrick DESIREE, Véronique TRAN (Licence 3 Dijon)
2015-2018: Coline CANOVAS (Master 2 CMPP + PhD)
2014: Camille ARBARERI (Master 2 CMPP)
2013: Sébastien GALOIS (Master 2 CMPP)


Collaborations

Prof Helmut Maecke, University of Freiburg, Germany
Dr Carmen Garrido, Inserm U866, Dijon
Dr Jessica Gobbo, CGFL, Dijon
Dr Frédéric Boschetti, Chematech, Quétigny
Aurélie Prignon, Laboratoire d’Imagerie Moléculaire Positonique (LIMP), Université Paris VI, Paris


Teaching at Université de Bourgogne


Funding

Conseil Régional de Bourgogne : 1-year Postdoc fellowship (2017-2018; Programme PARI II)
Agence Nationale pour la Recherche :
Programme JCJC (2017-2020; Site-specific dual-labeling of proteins)
France Life Imaging : "Amorce de collaborations" (2017-2018; in collaboration with Aurélie Prignon, Paris)
Conseil Régional de Bourgogne : Programme PARI II (2016; Project 2-P5 with F. Denat: Synthesis and evaluation of novel peptide derivatives by PET/SPECT and multimodal imaging)
Cancéropôle Grand-Est : "Soutien à l’Emergence de Projets" (2016; Imaging of Hsp70)
Ministère ESR : PhD fellowship - Coline Canovas (2015-2018)
Conseil Régional de Bourgogne :
Programme FABER (2013-2014; Peptides as targeting agents for nuclear imaging)





Academic degree
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ICMUB (UMR 5260) - University of Burgundy - Dijon (France)