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Dr Nicolas DESBOIS, Assistant Professor


Information
Academic organism : MENRT

Office : B-R23

Phone: +33 (0)3 80 39 61 23

E-mail : Nicolas.Desbois(at)u-bourgogne.fr

Education/Research Team : P2DA (Polyamines, Porphyrins, Developments and Applications)


Employment

Since September 2006: Assistant professor, University of Burgundy (86 section)

September 2004-August 2006: ATER (Teaching and Research Temporary Attache), Faculty of Pharmacy, Clermont-Ferrand, UMR INSERM 484, France.

Research topic:
- Synthesis of new platinum(II) complexes and antitumor activity
- Design, synthesis and biological activities of conformationally restricted analogs of primaquine
- Synthesis of iodoacridine and acridone carboxamide analogs of Amsacrine and DACA
- Cytotoxicity screens
- Studies with topoisomerase I
- Flow cytometry analysis
- Radioiodination
- Biodistribution in B16 melanoma bearing mice
- Colony forming.

 

Education

June 2005 : PhD in Organic Chemistry from Clermont-Ferrand, France (Dir. Pr. J. C. Teulade). With distinctions.

Design, synthesis and mechanism of action of heteroaromatic compounds for application to internal chemo radionuclide therapy of melanoma.

Research topic: Synthesis of polyfused heterocycles derivatives by Friedlander's reaction - Cytotoxicity screens - DNA intercalation with a synthetic oligodeoxynucleotide - Synthesis of iodoacridine and acridone carboxamides.

2002 : DEA Conception, Synthèse, Analyse et Structures de Composés d'Intérêt Biologiques (Masters degree in Organic Chemistry) University Orleans, ICOA, France. With distinctions.

2001 : Maîtrise de Chimie (First year of masters) University Blaise Pascal Clermont-Ferrand, France. With distinctions.

2000 : Licence de Chimie (Bachelor degree) University Blaise Pascal Clermont-Ferrand,     France.

 

Experiences

  • Organic Chemistry: Development of new synthesis methodologies in heterocyclic chemistry.
  • Experience in the spectroscopic identification of organic compounds (TLC, Recristallisation, IR, NMR).
  • Radiochemical synthesis (125I), purification by HPLC.
  • Cell biology: Cytotoxicity screens (Growth inhibition/cell kill (IC50), Resazurin reduction test, Hoechst dye 33342 assay); colony forming (proliferation test).
  • Topoisomerase I: Gel electrophoresis assay for the simultaneous determination of topoisomerase I inhibition, poisoning and DNA intercalation.
  • PC literate: Word, Excel, PowerPoint, Chemdraw, Mestre-C (NMR), Sci Finder Scholar, Beilstein.

Academic degree
    ...

ICMUB (UMR 5260) - University of Burgundy - Dijon (France)