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Prof. Franck DENAT, Director of the ICMUB

Academic organism : MENRT

Office : E-R17

Phone 1 : +33 (0)3 80 39 61 15

Phone 2 : +33 (0)3 80 39 61 17 (FAX)

E-mail : Franck.Denat(at)

Education/Research Team : P2DA (Polyamines, Porphyrins, Developments and Applications)

Since Jan. 2007 : Director of the Institute of Molecular Chemistry of the University of Burgundy (ICMUB, UMR CNRS 5260).
Since Sept. 2005 : Professor, University of Burgundy.
Sept. 1994-Aug. 2005 : Assistant/Associate Professor, Laboratoire d'Ingénierie Moléculaire pour la Séparation et les Applications des Gaz (LIMSAG), UMR 5633 CNRS, University of Burgundy, (Dir. Prof. Roger Guilard).
Aug. 1997-Aug. 1998 : Researcher (CNRS), University of California, Davis, USA (Prof. Kevin M. Smith).

2003 : "Habilitation" to supervise academic research in chemistry (Université de Bourgogne, Dijon).
1993 : Grade of Doctor in chemistry (Université Paul Sabatier, Toulouse) "Synthesis and reactivity of silyl-, germyl- and stannylpyrroles and pyrrolecarbaldehydes" (Dir. Prof. Jacques Dubac).


* Synthesis of macrocyclic polyamines (cyclam, cyclen, tacn, N- and C-functionalized derivatives)
* Design and synthesis of multifunctional chelating agents (BCA) for labeling biomolecules with radiometals (applications in molecular imaging)
* Design and synthesis of multimodal probes (fluorescence/PET/SPECT/MRI)
* Preparation of organic-inorganic hybrid materials (grafting of macrocycles on silica gel, sol-gel process)

→ 78 articles (h index 18), 12 patents (2 exploitation licenses), 115 communications, 19 invited lectures
→ co-foundation of CheMatech® company in 2005 (Concours Scientifique)
→ expert for ANR: non thématique, jeune chercheur, retour post-doc (member of the committee in 2009 and 2012)
→ reviewer for J. Am. Chem. Soc., Chem. Rev., Chem. Eur. J., New J. Chem., Eur. J. Org. Chem., Inorg. Chem., Tetrahedron, Tetrahedron Lett., Chem. Mater., J. Mater. Chem., Appl. Organomet. Chem., J. Incl. Phen., Synth. Commun., J. Mol. Struct., Biomacromolecules, Protein Pept. Lett., C.R. Acad. Sci, Int. J. Pept. Res. Ther., Bioconjugate Chem....
→ participation in 36 thesis and habilitation committees
→ Dina Surdin award (French Chemical Society) in 1994, NATO research grant in 1997-98


- 15 PhD students
- post-docs and master students (head of the "Chimie Moléculaire et Procédés Propres" Master's degree at the University of Burgundy since sept. 2004)


1. Bernhard, C.; Moreau, M.; Lhenry, D.; Goze, C.; Boschetti, F.; Rousselin, Y.; Brunotte, F.; Denat, F. "DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents" Chem. Eur. J. 2012, 18, 7834-7841
Moreau, M.; Raguin, O.; Vrigneaud, J.M.; Collin, B.; Bernhard, C.; Tizon, X.; Boschetti, F.; Duchamp, O.; Brunotte, F.; Denat, F. "DOTAGA-trastuzumab. A new antibody conjugate targeting HER2/neu antigen for diagnostic purpose" Bioconjugate Chem., 2012, 23, 1181-1188
Gros, C.P.; Eggenspiller, A.; Nonat, A.; Barbe, J.M.; Denat, F. "New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles" MedChemComm, 2011, 2, 119-125
Rousselin, Y.; Sok, N.; Boschetti, F.; Guilard, F.; Denat, F. "Efficient synthesis of new C-functionalized macrocyclic polyamines" Eur. J. Org. Chem., 2010, 1688-1693
Bernhard, C.; Goze, C.; Rousselin, Y.; Denat, F. "First bodipy-DOTA derivatives as probes for bimodal imaging" Chem. Commun., 2010, 46, 8267-8269

Academic degree
  • "Synhesis by directed metalation and reactivity of silyl-, germyl- and stannyl-pyrroles and pyrrolecarbaldehydes", Date 24/09/1993
  • University : Paul Sabatier University (Toulouse - France)
  • Advisor : DUBAC Jacques

ICMUB (UMR 5260) - University of Burgundy - Dijon (France)